Cell and gene therapy manufacturing is challenging enough, without relying on nature to produce the perfect ligand for your viral vector. Traditional ligand design approaches depend on chance – waiting for biology to deliver something that might work. At Tozaro we take the smarter path.
Tozaro blends molecular modeling, machine learning and chemical synthesis to design and build custom affinity ligands tailored to your viral vector and application.
From design to manufacture in a matter of weeks
Intelligently designed
By using in silico modeling to precisely map your target epitope, we identify the most accessible binding sites and design a polymer which is the perfect match.
Chemically synthesized
Drawing from our extensive library of chemical monomers, we engineer polymers with finely tuned binding kinetics – custom built to meet your exact requirements.
Rapidly scalable
Our polymers are animal component free and can be rapidly scaled up for manufacturing. Resulting in fast, cost-effective ligand production.
Unlock the power of smart affinity ligands
First class viral vector purification
Smart polymers can be immobilized on a range of chromatography scaffolds, unlocking gentler release conditions and higher yields of functional virus compared to traditional purification methods.
We’re working to improve viral vector analytics by combining smart affinity ligands with existing analytical platforms to get rapid, high throughput virus quantification.
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Tozaro designs and develops synthetic affinity reagents to enhance complex cell and gene therapy processes.
The smart polymer difference
Good process design is a function of reagent selection. Where reagent choice is restricted or where the selected reagent performance is a compromise, process efficiency is reduced both in terms of yield and quality. Tozaro’s unique reagent design and build is ideal for tackling difficult bioprocessing challenges. We not only create reagents which recognize and bind chosen epitopes on target molecules, we also tailor the reagent chemistry to your process to deliver the most impactful performance. Our reagents are scalable, so we can support our partners from development through to on market delivery.
Novel solutions for improving viral vector manufacture
We are using smart polymer technology to deliver marked improvements to viral vector analysis and purification, contributing to making therapies more cost effective, and accessible to patients. Use the links below to dive deeper into our core focus areas.
Viral Vector Analytics
We are developing a suite of Lentivirus and other synthetic affinity reagents for faster and more accurate viral vector analytics.
If you are not familiar with smart polymers, we have you covered. Take a look at our introductory guide to learn how Tozaro reagents are designed and developed to deliver new possibilities for the manufacture of cell and gene therapies.
